Metal-Free Construction of Multisubstituted Indolizines via Intramolecular Amination of Allylic Alcohols.
Xinxin LvPenghui GaoXiaowei ZhaoZhiyong JiangPublished in: The Journal of organic chemistry (2023)
An intramolecular amination of allylic alcohols is developed as an efficient and general access to biologically important multisubstituted indolizines and their variants. Two metal-free synthetic platforms including using aqueous hydrochloric acid solution as the solvent and p -toluenesulfonic acid as the catalyst have been established, enabling the divergent synthesis of these valuable compounds in high yields.