TIMP1 protects against blood-brain barrier disruption after subarachnoid haemorrhage by inhibiting ubiquitination of astrocytic β1-integrin.

Tianchi TangHuaijun ChenLibin HuJingya YeChaohui JingChaoran XuXinyan WuYike ChenZihang ChenHang ZhouLinfeng FanXiongjie FuCong QianJingsen ChenZhongju TanJing LiuHanhai ZengGao ChenFuyi Liu

Published in: Stroke and vascular neurology (2024)

TIMP1 inhibits the interaction between β1-integrin and Trim21 in astrocytes, thereby rescuing the ubiquitination of astrocytic β1-integrin. It subsequently restores interactions between astrocytic endfeet and the endothelium, as well as BBB integrity, eventually mitigating SAH-induced EBI.

Keyphrases

blood brain barrier
cell adhesion
cerebral ischemia
cell migration
nitric oxide
high glucose
oxidative stress
drug induced