Soluble B7-H4 blood serum levels are elevated in women at high risk for preeclampsia in the first trimester, as well as in patients with confirmed preeclampsia.
Pawel MachLuisa Nolte-BoenigkLeonie DrosteLaura FoxMirjam FrankBoerge SchmidtFlorian HerseStefan VerlohrenLukasz WicherekAntonella IannacconeCahit BirdirDimitrios AndrikosRainer KimmigAlexandra GellhausAngela KöningerPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2018)
sB7-H4 is involved in the regulation of immune tolerance in women with PE in the third trimester. In the first trimester of pregnancy, sB7-H4 might serve as a predictive immunological biomarker for women who are at elevated risk of developing PE.