Assembly of four modules onto a tetraazide platform by consecutive 1,2,3-triazole formations.
Suguru YoshidaYuki SakataYoshihiro MisawaTakamoto MoritaTomoko KuribaraHarumi ItoYuka KoikeIsao KiiTakamitsu HosoyaPublished in: Chemical communications (Cambridge, England) (2021)
Efficient consecutive 1,2,3-triazole formations using multiazide platforms are disclosed. On the basis of unique clickability of the 1-adamantyl azido group, a four-step synthesis of tetrakis(triazole)s was achieved from a tetraazide platform molecule. This method was applied to a convergent synthesis of tetrafunctionalized probes in a modular synthetic manner.