SNCA and mTOR Pathway Single Nucleotide Polymorphisms Interact to Modulate the Age at Onset of Parkinson's Disease.
Rubén Fernández-SantiagoNúria Martín-FloresFrancesca AntonelliCatalina CerqueraVerónica MorenoSara Bandres-CigaElisabetta ManduchiEduard TolosaAndrew B SingletonJason H Moorenull nullMaría-Josep MartíMario EzquerraCristina MalageladaPublished in: Movement disorders : official journal of the Movement Disorder Society (2019)
These findings indicate that genetic variability in the mTOR pathway contributes to SNCA effects in a nonlinear epistatic manner to modulate differential AAO in PD, unraveling the contribution of this cascade in the pathogenesis of the disease. © 2019 International Parkinson and Movement Disorder Society.