Interleukin-35 inhibited the production of histamine and pro-inflammatory cytokines through suppression MAPKs pathway in HMC-1 cells.

Li-Xin FuTao ChenQiao-Mei SunPei-Mei ZhouZai-Pei Guo

Published in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2021)

This study provides the first observations on the inhibitory and anti-inflammatory effect of IL-35 in activated HMC-1 cells. We suggest that IL35 may play an inhibited role in the pathogenesis of CSU.

Keyphrases

induced apoptosis
anti inflammatory
cell cycle arrest
endoplasmic reticulum stress
signaling pathway
oxidative stress