Efficacy of mixture of injectable-platelet rich fibrin and type-1 collagen particles on the closure of through-and-through periapical bone defects - A randomized controlled trial.

Endodontic microsurgery results in high success rate in large peripical lesions with through-and-through communication with more than 80% reduction in volume of lesion and size of both buccal and palatal window after one year. Mixture of type-1 collagen particles and i-PRF, adjunct to periapical micro-surgery did not improve the healing in through-and-through periapical defects.