Tumor volumes in T3 supraglottic cancers treated with radiotherapy in the modern era: A study of the Canadian Head & Neck Collaborative Research Initiative.
Nauman H MalikRui FuNicolin HaincChristopher W NoelJohn R de AlmeidaAli HosniShao Hui HuangEugene YuAgnieszka DziobaAndrew LeungArvindpaul MangatS Danielle MacNeilAnthony Charles NicholsShivaprakash B HiremathSantanu ChakrabortyAlborz JooyaMarc GaudetStephanie Johnson-ObasekiJonathan WhelanReza ForghaniMichael P HierGregoire B MorandKhalil SultanemJoseph C DortJohn LysackWayne MatthewsSteven C NakoneshnyGia GillAdam GlobermanPaul KerrPejman MaralaniIrene KaramAntoine EskanderPublished in: Head & neck (2023)
Increasing primary tumor volume is associated with worse OS and DFS in T3 supraglottic cancers treated with IMRT, with no clear threshold. The findings suggest that patients with larger tumors and poor baseline laryngeal function may benefit from upfront laryngectomy with adjuvant radiotherapy.