Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.
Kyu-Won ChoMark AndradeSeongho BaeSangsung KimJin Eyun KimEr Yearn JangSangho LeeAhsan HusainRoy L SutliffJohn W CalvertChangwon ParkYoung-Sup YoonPublished in: Circulation (2023)
Our results demonstrate that CBX7 directs the cell cycle exit of cardiomyocytes during the postnatal period by regulating its downstream targets TARDBP and RBM38. This is the first study to demonstrate the role of CBX7 in regulation of cardiomyocyte proliferation, and CBX7 could be an important target for cardiac regeneration.