Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis.
Lijun LiaoKai Markus SchneiderEric J C GalvezMick FrissenHanns-Ulrich MarschallHuan SuMaximilian HattingAnnika WahlströmJohannes HaybaeckPhilip PuchasAntje MohsJin PengIna BergheimAnika NierJulia HenningsJohanna ReißingHenning W ZimmermannThomas LongerichTill StrowigChristian LiedtkeFrancisco Javier CuberoChristian TrautweinPublished in: Gut (2019)
MDR2-associated cholestasis triggers intestinal dysbiosis. In turn, translocation of endotoxin into the portal vein and subsequent NLRP3 inflammasome activation contribute to higher liver injury. This process does not essentially depend on caspase-8 in hepatocytes, but can be blocked by IDN-7314.