HbS/β+ thalassemia: Really a mild disease? A National survey from the AIEOP Sickle Cell Disease Study Group with genotype-phenotype correlation.
Lucia Dora NotarangeloAnnalisa AgostiniMaddalena CasalePiera SamperiFrancesco ArcioniPaolo GorelloSilverio PerrottaNicoletta MaseraAngelica BaroneElisa BertoniElisa BonettiRoberta BurnelliTommaso CasiniGiovanni Carlo Del VecchioBeatrice FilippiniFiorina GionaPaola GiordanoChiara GorioEleonora MarchinaMargherita NardiAngela PetroneRaffaella ColombattiLaura SainatiGiovanna RussoPublished in: European journal of haematology (2019)
HbS/β+ is not always a mild disease. Patients with IVS-I-110 mutation could benefit from a standard of care like SS and S/β° patients. Standardization of treatment is needed.