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Natural Killer T-like Cells: Immunobiology and Role in Disease.

Jani-Sofia AlmeidaJosé Manuel CasanovaManuel Santos-RosaRaquel TarazonaRafael SolanaPaulo Rodrigues-Santos
Published in: International journal of molecular sciences (2023)
CD56+ T cells are generally recognized as a distinct population of T cells and are categorized as NKT-like cells. Although our understanding of NKT-like cells is far from satisfactory, it has been shown that aging and a number of disease situations have impacted these cells. To construct an overview of what is currently known, we reviewed the literature on human NKT-like cells. NKT-like cells are highly differentiated T cells with "CD1d-independent" antigen recognition and MHC-unrestricted cell killing. The genesis of NKT-like cells is unclear; however, it is proposed that the acquisition of innate characteristics by T cells could represent a remodeling process leading to successful aging. Additionally, it has been shown that NKT-like cells may play a significant role in several pathological conditions, making it necessary to comprehend whether these cells might function as prognostic markers. The quantification and characterization of these cells might serve as a cutting-edge indicator of individual immune health. Additionally, exploring the mechanisms that can control their killing activity in different contexts may therefore result in innovative therapeutic alternatives in a wide range of disease settings.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • healthcare
  • public health
  • systematic review
  • oxidative stress
  • cell death
  • climate change
  • risk assessment
  • health information
  • human health