Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID.
Connor B GradyBornali BhattacharjeeJulio SilvaJillian JaycoxLik Wee LeeValter Silva MonteiroMitsuaki SawanoDaisy MasseyCésar CaraballoJeff R GehlhausenAlexandra TabachnikovaTianyang MaoCarolina LucasMario A Peña-HernandezLan XuTiffany J TzengTakehiro TakahashiJeph HerrinDiana Berrent GütheAthena AkramiGina AssafHannah DavisKaren HarrisLisa McCorkellWade L SchulzDaniel GrffinHannah WeiAaron M RingLeying GuanCharles Dela CruzAkiko IwasakiHarlan M KrumholzPublished in: medRxiv : the preprint server for health sciences (2024)
Our study showed that in this small sample, vaccination improved the health or resulted in no change to the health of most participants, though few experienced worsening. Vaccination was associated with increased SARS-CoV-2 Spike protein-specific IgG and T cell expansion in most individuals with Long COVID. Symptom improvement was observed in those with baseline elevated sIL-6R, while elevated interferon and neuropeptide levels were associated with a lack of improvement.