Acid-Sensitive Nanoparticles Based on Molybdenum Disulfide for Photothermal-Chemo Therapy.
Qin LiuPing SongWeiwei ZhangZhenyu WangKai YangJianquan LuoLongbao ZhuLin GuiYugui TaoFei GePublished in: ACS biomaterials science & engineering (2022)
The combination of multiple treatments has recently been investigated for tumor treatment. In this study, molybdenum disulfide (MoS 2 ) with excellent photothermal conversion performance was used as the core, and manganese dioxide (MnO 2 ), which responds to the tumor microenvironment, was loaded on its surface by liquid deposition to form a mesoporous core-shell structure. Then, the chemotherapeutic drug Adriamycin (DOX) was loaded into the hole. To further enhance its water solubility and stability, the surface of MnO 2 was modified with mPEG-NH 2 to prepare the combined antitumor nanocomposite MoS 2 @DOX/MnO 2 -PEG (MDMP). The results showed that MDMP had a diameter of about 236 nm, its photothermal conversion efficiency was 33.7%, and the loading and release rates of DOX were 13 and 65%, respectively. During in vivo and in vitro studies, MDMP showed excellent antitumor activity. Under the combined treatment, the tumor cell viability rate was only 11.8%. This nanocomposite exhibits considerable potential for chemo-photothermal combined antitumor therapy.
Keyphrases
- cancer therapy
- photodynamic therapy
- drug delivery
- quantum dots
- reduced graphene oxide
- drug release
- room temperature
- combination therapy
- highly efficient
- stem cells
- emergency department
- visible light
- ionic liquid
- optical coherence tomography
- human health
- atomic force microscopy
- mass spectrometry
- high speed
- perovskite solar cells
- chemotherapy induced
- adverse drug