Quantification and role of innate lymphoid cell subsets in Chronic Obstructive Pulmonary Disease.
Evy E BlommeSharen ProvoostElise G De SmetKatrien C De GroveHannelore P Van EeckhoutteJoyceline De VolderPhilip M HansbroMatteo BonatoMarina SaettaSara Ra WijnantFien VerhammeGuy F JoosKen R BrackeGuy G BrusselleTania MaesPublished in: Clinical & translational immunology (2021)
The ILC1 subset is increased in COPD patients and correlates with smoking and severity of respiratory symptoms. ILCs also increase upon CS exposure in C57BL/6J mice. In the absence of adaptive immunity, ILCs contribute to CS-induced pro-inflammatory mediator release, but are redundant in CS-induced innate inflammation.
Keyphrases
- end stage renal disease
- high glucose
- diabetic rats
- immune response
- oxidative stress
- chronic kidney disease
- newly diagnosed
- ejection fraction
- chronic obstructive pulmonary disease
- peritoneal dialysis
- single cell
- type diabetes
- cell therapy
- lung function
- adipose tissue
- metabolic syndrome
- mesenchymal stem cells
- peripheral blood
- sleep quality