Characterization of T lymphocytes in severe COVID-19 patients.

Daniela FenoglioChiara DentoneAlessia ParodiAntonio Di BiagioFederica BozzanoAntonio VenaMarina FabbiFrancesca FerreraTiziana AltosoleBianca BruzzoneMauro GiacominiPaolo PelosiAndrea De Maria Matteo BassettiRaffaele De PalmaGilberto Filaci

Published in: Journal of medical virology (2021)

In this observational study, 13 patients with severe COVID-19 and 10 healthy controls were enrolled. The data concerning the analysis of circulating T cells show that, in severe COVID-19 patients, the expansion of these cell compartments is prone to induce antibody response, inflammation (CCR4+ and CCR6+ TFH) and regulation (CD8+ Treg). This pathogenic mechanism could lead us to envision a possible new form of biological target therapy.

Keyphrases

sars cov
early onset
coronavirus disease
oxidative stress
dendritic cells
regulatory t cells
single cell
cell therapy
electronic health record
drug induced
bone marrow
mesenchymal stem cells
immune response
nk cells
artificial intelligence
deep learning
smoking cessation