Axonal Injury Partially Mediates Associations Between Increased Left Ventricular Mass Index and White Matter Damage.
Elizabeth E MooreOmair A KhanNiranjana ShashikumarKimberly R PechmanDandan LiuSusan P BellSangeeta NairJames G TerryKatherine A GiffordAdam W AndersonBennett A LandmanKaj BlennowHenrik ZetterbergTimothy J HohmanJohn Jeffrey CarrAngela L JeffersonPublished in: Stroke (2021)
Subclinical cardiovascular remodeling, measured as an increase in LV mass index, is associated with neuroaxonal degeneration among individuals with MCI and APOE-ɛ4. Neuroaxonal degeneration partially reflects associations between higher LV mass index and white matter damage. Findings highlight neuroaxonal degeneration, rather than amyloidosis or microglia, may be more relevant in pathways between structural cardiovascular remodeling and white matter damage.