Route to Functionalized Tetrahydrobenzo[ d ]azepines via Re 2 O 7 -Mediated Intramolecular Friedel-Crafts Reaction.

We describe a Re 2 O 7 -mediated intramolecular dehydrative Friedel-Crafts reaction for the efficient synthesis of various benzo-fused heterocycles such as benzazepines and benzazocines. This process is characterized by a broad substrate scope, mild reaction conditions, high efficiency, and high atom economy. The potential application of this methodology was exemplified by the facile preparation of a NMDA antagonist as well as a key intermediate en route to SKF 38393.