Pharmacokinetics of cefiderocol during extracorporeal membrane oxygenation: A case report.
Jordi RieraLaura DomenechSonia GarcíaPau-Parra AlbaManuel SosaJosep DomenechClara PalmadaPau TorrellaAriadna SánchezAnna LamoraElisabet GallartPilar GirónXavier NuvialsRicard FerrerPublished in: Perfusion (2023)
Patients with extracorporeal membrane oxygenation (ECMO) support do frequently receive broad-spectrum antibiotics, due to the high frequency of infection by multidrug resistant microorganisms. The extracorporeal circuit can alter the pharmacokinetics (PK) of administered drugs, and in the case of antibiotics this may lead to treatment failure. Cefiderocol is a new cephalosporin that exhibits excellent in vitro activity against many multidrug-resistant (MDR) microorganisms, but there is no published data about the modifications of its PK in patients with ECMO support. Herein we report the results of a pharmacokinetic investigation of cefiderocol in a critically ill patient receiving extracorporeal respiratory support.
Keyphrases
- extracorporeal membrane oxygenation
- gram negative
- multidrug resistant
- high frequency
- acute respiratory distress syndrome
- drug resistant
- acinetobacter baumannii
- respiratory failure
- transcranial magnetic stimulation
- klebsiella pneumoniae
- mechanical ventilation
- case report
- pseudomonas aeruginosa
- systematic review
- big data
- intensive care unit
- meta analyses