The characteristics of the ancient cell death suppressor, TMBIM6, and its related signaling pathways after endoplasmic reticulum stress.
Desislava DoychevaHarpreet KaurJi-Ping TangArne P NeyrinckPublished in: Journal of neuroscience research (2019)
Activation of the unfolded protein response in combination with generation of reactive oxygen species, from cytochrome P450 members and NADPH-P450 reductases, are two major consequences of Endoplasmic Reticulum (ER) stress that cause oxidative damage and cell death. Herein, we reviewed the role of Bax Inhibitor-1 (BI-1), an evolutionarily conserved protein encoded by the Transmembrane Bax inhibitor Motif Containing 6 gene, in protection from ER stress. As BI-1 has multimodal properties that can target a wide array of pathophysiological consequences after injury, our main objective was to explore BI-1's protective role in ER stress and its potential signaling pathways.
Keyphrases
- endoplasmic reticulum stress
- induced apoptosis
- cell death
- endoplasmic reticulum
- signaling pathway
- cell cycle arrest
- protein protein
- oxidative stress
- pi k akt
- binding protein
- transcription factor
- epithelial mesenchymal transition
- genome wide
- pain management
- copy number
- dna methylation
- gene expression
- small molecule
- cell proliferation
- high density