Tetrahydrocurcumin, a major metabolite of curcumin, ameliorates allergic airway inflammation by attenuating Th2 response and suppressing the IL-4Rα-Jak1-STAT6 and Jagged1/Jagged2 -Notch1/Notch2 pathways in asthmatic mice.

Bin Lin ChenYan Qiu ChenBai Hui MaSi Fei YuLi Yue LiQing Xiang ZengYu Tao ZhouYin Fan WuWen Long LiuJian Bo WanYan YangChun Wei Li

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2018)

The above results demonstrated for the first time that THC was superior to Cur in modulating allergic asthmatic phenotypes, especially attenuating the Th2 response. THC might be a potentially effective agent for asthma treatment.

Keyphrases

lung function
allergic rhinitis
signaling pathway
cell proliferation
mouse model
type diabetes
high fat diet induced
adipose tissue
combination therapy
smoking cessation
replacement therapy