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Epithelial to mesenchymal transition in human endocrine islet cells.

José Luis Moreno-AmadorNoèlia TéllezSandra MarinCaterina Aloy-RevertéCarlos SeminoMontserrat NacherEduard Montanya
Published in: PloS one (2018)
In adult human islets, all four endocrine islet cell types undergo EMT when islet cells are expanded in monolayer conditions. The presence of EMT in all islet endocrine cells could be relevant to design of strategies aiming to re-differentiate the expanded islet cells towards a β-cell phenotype.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • endothelial cells
  • endoplasmic reticulum stress
  • single cell
  • cell therapy
  • stem cells
  • cell death
  • signaling pathway
  • bone marrow
  • pi k akt