Pharmacokinetics of doxorubicin following concomitant intravenous administration of olaratumab (IMC-3G3) to patients with advanced soft tissue sarcoma.
Victor M VillalobosGary MoMark AgulnikSeth M PollackDaniel A RushingArun SinghBrian Andrew Van TineRhian McNaughtonRodney L DeckerWei ZhangAshwin ShahirDamien M CronierPublished in: Cancer medicine (2019)
Olaratumab at 15 or 20 mg/kg before doxorubicin infusion had no clinically relevant effect on systemic exposure to doxorubicin compared with doxorubicin alone in patients with metastatic or locally advanced STS.