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Pharmacological ablation of astrocytes reduces Aβ degradation and synaptic connectivity in an ex vivo model of Alzheimer's disease.

Nicola DavisBibiana C MotaLarissa SteadEmily O C PalmerLaura LombarderoRafael Rodríguez-PuertasVincenzo de PaolaSamuel J BarnesMagdalena Sastre
Published in: Journal of neuroinflammation (2021)
Astrocytes play a protective role in AD by aiding Aβ clearance and supporting synaptic plasticity.
Keyphrases
  • resting state
  • cognitive decline
  • white matter
  • functional connectivity
  • mild cognitive impairment