Can low-dose methotrexate reduce effusion-synovitis and symptoms in patients with mid- to late-stage knee osteoarthritis? Study protocol for a randomised, double-blind, and placebo-controlled trial.

Zhaohua ZhuQinghong YuXiaomei LengWeiyu HanZhanguo LiCibo HuangJieruo GuYi ZhaoKang WangTianwang LiYifang MeiJianhua XuZhiyi ZhangDavid HunterFlavia CicuttiniXiaofeng ZengChanghai Ding

Published in: Trials (2020)

ClinicalTrials.gov NCT03815448 . Registered on 21 January 2019.

Keyphrases

knee osteoarthritis
double blind
low dose
high dose
placebo controlled
clinical trial
phase iii
study protocol
phase ii
sleep quality
open label
depressive symptoms
physical activity