Factors associated with severity of COVID-19 disease in a multicenter cohort of people with HIV in the United States, March-December 2020.
Adrienne E ShapiroRachel Bender IgnacioBridget M WhitneyJoseph A Chris DelaneyRobin M NanceLaura BamfordDarcy WootenJeanne C KerulyGreer A BurkholderSonia NapravnikKenneth H MayerAllison R WebelH Nina KimStephen E Van RompaeyKaterina A ChristopoulosJeffrey JacobsonMaile Ann Young KarrisDavey M SmithMallory O JohnsonAmanda WilligJoseph J EronPeter W HuntRichard D MooreMichael S SaagW Christopher MathewsHeidi M CraneEdward R CachayMari M Kitahatanull nullPublished in: medRxiv : the preprint server for health sciences (2021)
PWH with CD4 <350 cells/mm 3 , low CD4/CD8 ratio, and history of CD4 <200, have a clear excess risk of severe COVID-19, after accounting for comorbidities also associated with severe outcomes. PWH with these risk factors should be prioritized for COVID-19 vaccination, early treatment, and monitored closely for worsening illness.