A family-based genome-wide association study reveals an association of spondyloarthritis with MAPK14.

Félicie CostantinoAlice TalpinRoula Said-NahalAriane LeboimeElena ZinovievaDiana ZelenikaIvo GutCéline CharonBrigitte IzacMichael WeissmanGilles ChiocchiaJohn D Reveille Maxime BrebanHenri-Jean Garchon

Published in: Annals of the rheumatic diseases (2016)

We report here for the first time a family-based GWAS study on SpA and identified an associated polymorphism near MAPK14. Further analyses are needed to better understand the functional basis of this genetic association.

Keyphrases

genome wide association study
signaling pathway
oxidative stress
pi k akt
ankylosing spondylitis
gene expression
systemic lupus erythematosus