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A Sleep-Specific Midbrain Target for Sevoflurane Anesthesia.

Tingting YiNa WangJing HuangYaling WangShuancheng RenYiwen HuJianxia XiaYixiang LiaoXin LiFenlan LuoQin OuyangYu LiZiyi ZhengQin XiaoRong RenZhongxiang YaoXiangdong TangYanjiang WangXiaowei ChenChao HeHong LiZhian Hu
Published in: Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2023)
Sevoflurane has been the most widely used inhaled anesthetics with a favorable recovery profile; however, the precise mechanisms underlying its anesthetic action are still not completely understood. Here the authors show that sevoflurane activates a cluster of urocortin 1 (UCN1 + )/cocaine- and amphetamine-regulated transcript (CART + ) neurons in the midbrain involved in its anesthesia. Furthermore, growth hormone secretagogue receptor (GHSR) is highly enriched in sevoflurane-activated UCN1 + /CART + cells and is necessary for sleep induction. Blockade of GHSR abolishes the excitatory effect of sevoflurane on UCN1 + /CART + neurons and attenuates its anesthetic effect. Collectively, their data suggest that anesthetic action of sevoflurane necessitates the GHSR activation in midbrain UCN1 + /CART + neurons, which provides a novel target including the nucleus and receptor in the field of anesthesia.
Keyphrases
  • growth hormone
  • spinal cord
  • induced apoptosis
  • sleep quality
  • cystic fibrosis
  • cell cycle arrest
  • machine learning
  • spinal cord injury
  • cell proliferation
  • rna seq
  • single cell
  • deep learning