Evaluation of a First PET Tracer Suitable for Imaging the Sigma-2 Receptor in the Brain of Nonhuman Primates.
Santosh Reddy AlluriMingQiang ZhengDaniel HoldenYing ZhangLi ZhangZachary FelchnerSongye LiJim RopchanRichard CarsonHongmei JiaYiyun HuangPublished in: Molecular pharmaceutics (2023)
The sigma-2 receptor (σ2R), recently identified as transmembrane protein 97, is expressed in many cell types and mediates important functions in both the peripheral and central nervous systems. Over the years, σ2R has emerged as a potential therapeutic target for cancer and neurological disorders such as Alzheimer's disease (AD). The currently available σ2R radiotracers have been developed primarily for cancer imaging with limited brain uptake. Here, we report the evaluation of the first brain penetrant 18 F-labeled radiotracer suitable for positron emission tomography (PET) imaging of σ2R in nonhuman primate brain.
Keyphrases
- pet imaging
- positron emission tomography
- resting state
- computed tomography
- white matter
- papillary thyroid
- high resolution
- cerebral ischemia
- functional connectivity
- pet ct
- squamous cell carcinoma
- single cell
- binding protein
- stem cells
- lymph node metastasis
- cognitive decline
- blood brain barrier
- mesenchymal stem cells
- small molecule
- amino acid