The effect of post-stroke hyperglycaemia on the levels of brain damage and repair-related circulating biomarkers: the Glycaemia in Acute Stroke Study II.

L Otero-OrtegaM Gutiérrez-FernándezR Gutiérrez-ZúñigaR Madero-JaraboM Alonso de LeciñanaF Laso-GarcíaA LisbonaR Delgado-MederosJ Gállego-CulleréM Martínez-ZabaletaM FreijoJ C PortillaA Gil-NúñezE Díez-TejedorBlanca Fuentesnull null

Published in: European journal of neurology (2019)

Post-stroke hyperglycaemia appears to be associated with a negative regulation of BDNF and a different reaction in EPC levels. However, neither BDNF nor EPCs showed significant mediation of the PSH association with IS outcome, and only higher interleukin-6 in the follow-up samples (72-96 h) was related to poor outcomes, independently of PSH status. Further studies are needed to achieve definite conclusions.

Keyphrases

oxidative stress
stress induced
type diabetes
adipose tissue
metabolic syndrome
insulin resistance
case control
brain injury
weight loss