All trans-retinoic acid protects against acute ischemic stroke by modulating neutrophil functions through STAT1 signaling.

Wei CaiJulie WangMengyan HuXiao ChenZhengqi LuJoseph A BellantiSong Guo Zheng

Published in: Journal of neuroinflammation (2019)

atRA displays potent therapeutic efficacy in ischemic stroke by attenuating neural inflammation. Treatment of atRA impeded neutrophil accumulation, favored N2 polarization, and forbade NETs formation in ischemic lesion. STAT1 signaling played a decisive role in the mechanisms of atRA-afforded regulation to neutrophil.

Keyphrases

acute ischemic stroke
cell proliferation
oxidative stress
signaling pathway
combination therapy
anti inflammatory
replacement therapy