Targeting the phosphorylation site of myristoylated alanine-rich C kinase substrate alleviates symptoms in a murine model of steroid-resistant asthma.

Chien-Neng WangYu-Chao LinBo-Chun ChangChing-Hsien ChenReen WuChen-Chen Lee

Published in: British journal of pharmacology (2019)

Our findings indicate that targeting MARCKS phosphorylation through MPS treatment may inhibit neutrophilic inflammation and relieve asthma symptoms, thereby highlighting its potential as a therapeutic agent for steroid-resistant asthma.

Keyphrases

chronic obstructive pulmonary disease
lung function
allergic rhinitis
protein kinase
cancer therapy
oxidative stress
sleep quality
cystic fibrosis
air pollution
mouse model
depressive symptoms
smoking cessation
replacement therapy