In vivo absolute quantification of striatal and extrastriatal D2/3 receptors with [123I]epidepride SPECT.

A partial saturation method allowed the robust quantification of D2/3 receptors in striatal and extrastriatal D2/3 receptors with a single-scan approach. This approach may be applied in the mapping of the D2/3 receptor in translational biological studies and potentially, in clinical SPECT imaging.