Recombinant α-Klotho Protein Alleviated Acute Cardiorenal Injury in a Mouse Model of Lipopolysaccharide-Induced Septic Cardiorenal Syndrome Type 5.
Xi LiuYangyang NiuXiaoqin ZhangYingying ZhangYing YuJieli HuangJiangtao LiChen YuPublished in: Analytical cellular pathology (Amsterdam) (2019)
α-Klotho significantly alleviates acute cardiorenal injury in LPS-induced septic cardiorenal injury due to the inhibition of apoptosis, inflammation, and oxidation, as well as the regulation of endoplasmic reticulum stress levels.
Keyphrases
- endoplasmic reticulum stress
- lipopolysaccharide induced
- inflammatory response
- lps induced
- mouse model
- liver failure
- induced apoptosis
- oxidative stress
- respiratory failure
- acute kidney injury
- drug induced
- aortic dissection
- cell death
- hydrogen peroxide
- cell cycle arrest
- signaling pathway
- hepatitis b virus
- extracorporeal membrane oxygenation
- binding protein
- cell free
- acute respiratory distress syndrome