Hypoalbuminaemia and decreased midazolam clearance in terminally ill adult patients, an inflammatory effect?

Linda G W FrankenAnniek D MasmanBrenda C M de WinterFrans P M BaarDick TibboelTeun van GelderBirgit C P KochRon A A Mathot

Published in: British journal of clinical pharmacology (2017)

Our study indicates albumin levels and eGFR as relevant clinical parameters to optimize midazolam dosing in terminally ill patients. The correlation between low albumin levels and decreased midazolam clearance is probably a result of inflammatory response as high CRP levels were correlated in a similar way.

Keyphrases

inflammatory response
end stage renal disease
small cell lung cancer
ejection fraction
newly diagnosed
oxidative stress
epidermal growth factor receptor
peritoneal dialysis
lipopolysaccharide induced
lps induced
patient reported