Blunted leptin sensitivity during hedonic overeating can be reinstated by activating galanin 2 receptors (Gal2R) in the lateral hypothalamus.
Este LeidmaaMary GazeaAlexandre V PatchevAnna PissiotiNils Christian GassenMayumi KimuraZsolt LipositsImre KalloOsborne F X AlmeidaPublished in: Acta physiologica (Oxford, England) (2019)
Hedonically-loaded foods interrupt the inhibitory actions of leptin on orexin neurons and interfere with the homeostatic control of feeding. Overeating of palatable foods can be curtailed in lean animals by activating Gal2R in the lateral hypothalamus.