Construction of a sequentially responsive nanocarrier for chemotherapy and cascade amplified NIR photodynamic therapy.
Tao YanLinlin RenFengyan LiFeng TianChengfang JiangQi WangXinyue SongShu-Sheng ZhangPublished in: Chemical communications (Cambridge, England) (2022)
A sequentially responsive nanocarrier was fabricated with three-in-one functional integration: bio-imaging, tumor microenvironment responsive chemotherapy and cascade activation of upconversion photodynamic therapy. The designed DNA outer nanoshell displayed site-specific degradation and controlled degradation speed. Significantly, the developed controllable nanotheranostic agent displayed high cell apoptosis ratios and obvious tumor inhibition.