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Construction of a sequentially responsive nanocarrier for chemotherapy and cascade amplified NIR photodynamic therapy.

Tao YanLinlin RenFengyan LiFeng TianChengfang JiangQi WangXinyue SongShu-Sheng Zhang
Published in: Chemical communications (Cambridge, England) (2022)
A sequentially responsive nanocarrier was fabricated with three-in-one functional integration: bio-imaging, tumor microenvironment responsive chemotherapy and cascade activation of upconversion photodynamic therapy. The designed DNA outer nanoshell displayed site-specific degradation and controlled degradation speed. Significantly, the developed controllable nanotheranostic agent displayed high cell apoptosis ratios and obvious tumor inhibition.
Keyphrases
  • photodynamic therapy
  • fluorescence imaging
  • cancer therapy
  • drug delivery
  • locally advanced
  • high resolution
  • single molecule
  • squamous cell carcinoma
  • radiation therapy