Identifying aggressive prostate cancer foci using a DNA methylation classifier.

Kamilla MundbjergSameer ChopraMehrdad AlemozaffarChristopher DuymichRanjani LakshminarasimhanPeter W NicholsManju AronKimberly D SiegmundOsamu UkimuraMonish AronMariana SternParkash GillJohn D CarptenTorben F ØrntoftKarina D SørensenDaniel J WeisenbergerPeter A JonesVinay DuddalwarInderbir GillGangning Liang

Published in: Genome biology (2017)

Overall, this study provides molecular-based support for determining PC aggressiveness with the potential to impact clinical decision-making, such as targeted biopsy approaches for early diagnosis and active surveillance, in addition to focal therapy.

Keyphrases

prostate cancer
dna methylation
decision making
radical prostatectomy
gene expression
genome wide
ultrasound guided
stem cells
single molecule
drug delivery
climate change
mesenchymal stem cells
copy number
fine needle aspiration