Identifying aggressive prostate cancer foci using a DNA methylation classifier.
Kamilla MundbjergSameer ChopraMehrdad AlemozaffarChristopher DuymichRanjani LakshminarasimhanPeter W NicholsManju AronKimberly D SiegmundOsamu UkimuraMonish AronMariana SternParkash GillJohn D CarptenTorben F ØrntoftKarina D SørensenDaniel J WeisenbergerPeter A JonesVinay DuddalwarInderbir GillGangning LiangPublished in: Genome biology (2017)
Overall, this study provides molecular-based support for determining PC aggressiveness with the potential to impact clinical decision-making, such as targeted biopsy approaches for early diagnosis and active surveillance, in addition to focal therapy.