Human CD141+ dendritic cells (cDC1) are impaired in patients with advanced melanoma but can be targeted to enhance anti-PD-1 in a humanized mouse model.

Yoke Seng LeeLiam J O'BrienCarina M WalpoleFrances E PearsonIngrid M Leal-RojasKelly-Anne MastermanVictoria AtkinsonAndrew BarbourKristen J Radford

Published in: Journal for immunotherapy of cancer (2021)

These data illustrate quantitative and qualitative impairments in circulating CD141+ DCs in patients with advanced melanoma and that increasing CD141+ DC number and function is an attractive strategy to enhance immunogenicity and response rates to ICIs.

Keyphrases

dendritic cells
mouse model
endothelial cells
nk cells
immune response
systematic review
high resolution
regulatory t cells
electronic health record
cell cycle
machine learning
mass spectrometry
cancer therapy
deep learning
monoclonal antibody
artificial intelligence