Drug-induced liver injury associated with severe cutaneous adverse drug reactions: A nationwide study in Taiwan.

Yi-Shin HuangChen-Yi WuTing-Tsung ChangCheng-Yuan Peng Gin-Ho LoChao-Wei HsuChi-Tan HuYi-Hsiang Huang

Published in: Liver international : official journal of the International Association for the Study of the Liver (2021)

DILI patients combined with SCAR are common and have a high mortality in Taiwan. Allopurinol is the leading incriminated drug. Jaundice, acute kidney injury and SJS/TEN are risk factors of mortality. HLA-B*5801, chronic kidney disease and high drug dosage also contribute to high mortality in allopurinol-induced DILI with SCAR.

Keyphrases

electronic health record
adverse drug
drug induced
risk factors
end stage renal disease
chronic kidney disease
cardiovascular events
acute kidney injury
ejection fraction
emergency department
high glucose
type diabetes
diabetic rats
oxidative stress
coronary artery disease
stress induced