Randomized Trial of Platelet-Transfusion Thresholds in Neonates.

Anna CurleySimon J StanworthKaren WilloughbySusanna F Fustolo-GunninkVidheya VenkateshCara HudsonAlison DearyRenate HodgeValerie HopkinsBeatriz Lopez SantamariaAna MoraCharlotte LlewelynAngela D'AmoreRizwan KhanWes OnlandEnrico LoprioreKarin FijnvandraatHelen NewPaul ClarkeTimothy Wattsnull null

Published in: The New England journal of medicine (2018)

Among preterm infants with severe thrombocytopenia, those randomly assigned to receive platelet transfusions at a platelet-count threshold of 50,000 per cubic millimeter had a significantly higher rate of death or major bleeding within 28 days after randomization than those who received platelet transfusions at a platelet-count threshold of 25,000 per cubic millimeter. (Funded by the National Health Service Blood and Transplant Research and Development Committee and others; Current Controlled Trials number, ISRCTN87736839 .).

Keyphrases

preterm infants
low birth weight
cardiac surgery
atrial fibrillation
early onset
quality improvement
acute kidney injury
sickle cell disease
drug induced