Fucoidan Structure and Its Impact on Glucose Metabolism: Implications for Diabetes and Cancer Therapy.
Blessing MabateChantal Désirée DaubSamkelo MalgasAdrienne Lesley EdkinsBrett Ivan PletschkePublished in: Marine drugs (2021)
Fucoidans are complex polysaccharides derived from brown seaweeds which consist of considerable proportions of L-fucose and other monosaccharides, and sulphated ester residues. The search for novel and natural bioproduct drugs (due to toxicity issues associated with chemotherapeutics) has led to the extensive study of fucoidan due to reports of it having several bioactive characteristics. Among other fucoidan bioactivities, antidiabetic and anticancer properties have received the most research attention in the past decade. However, the elucidation of the fucoidan structure and its biological activity is still vague. In addition, research has suggested that there is a link between diabetes and cancer; however, limited data exist where dual chemotherapeutic efforts are elucidated. This review provides an overview of glucose metabolism, which is the central process involved in the progression of both diseases. We also highlight potential therapeutic targets and show the relevance of fucoidan and its derivatives as a candidate for both cancer and diabetes therapy.
Keyphrases
- type diabetes
- papillary thyroid
- cardiovascular disease
- glycemic control
- cancer therapy
- squamous cell
- drug delivery
- working memory
- oxidative stress
- electronic health record
- emergency department
- lymph node metastasis
- skeletal muscle
- quality improvement
- stem cells
- risk assessment
- machine learning
- big data
- weight loss
- young adults
- water soluble
- cell wall