Frailty and affective disorders throughout adult life: a 5-year follow-up of the Lifelines Cohort Study.
Marcus K BorgesHans W JeuringRadboud M MarijnissenBarbara C van MunsterIvan AprahamianRob H S van den BrinkEmiel O HoogendijkRichard C Oude VoshaarPublished in: Journal of the American Geriatrics Society (2022)
Affective disorders are reciprocally related to frailty. Results with respect to the impact of anxiety disorders on frailty suggest most impact at lower levels of frailty. Our results might imply that interventions to slow biological aging should be broadened towards younger and middle-aged people as well as non-frail older patients. To develop targeted treatment, future clinical and epidemiologic studies on the underlying pathways of this bidirectional association are needed.