Targeting the oncogenic m6A demethylase FTO suppresses tumourigenesis and potentiates immune response in hepatocellular carcinoma.

Ao ChenVanilla Xin ZhangQingyang ZhangKaren Man-Fong SzeLu TianHongyang HuangXia WangEva LeeJingyi LuXueying LyuMan-Fong Joyce LeeChun Ming WongDaniel Wai-Hung HoIrene Oi Lin Ng

Published in: Gut (2024)

Targeting the FTO/m6A/GPNMB axis could significantly suppress tumour growth and metastasis, and enhance immune activation, highlighting the potential of targeting FTO signalling with effective inhibitors for HCC therapy.

Keyphrases

immune response
cancer therapy
signaling pathway
drug delivery
bone marrow
toll like receptor
climate change
inflammatory response
human health
replacement therapy