Chemical Composition of Achillea millefolium L. and Their Anti-Inflammatory Activity.
Xinge HuangNannan XuZhitao LiuHongliang LiHui LuJun LiPublished in: Chemistry & biodiversity (2024)
A new monoterpene, (-)-10-hydroxydihydroactinidiolide (1), along with two known monoterpenes, loliolide (2) and (+)-isololiolide (3), three known megastigmanes, 3α-hydroxy-5β,6β-epoxy-β-ionone (4), 3α-hydroxy-5α,6α-epoxy-β-ionone (5), and (+)-dehydrovomifoliol (6), a eudesmane-type sesquiterpene, 4α-hydroxy-4β-methyldihydrocostol (7), a monoterpene, 8-hydroxycarvotanacetone (8), two flavonoids, chrysoeriol (9) and apigenin (10), and a phenylpropanoid, 3-(4-hydroxyphenyl)-1-propanol (11), were isolated from the whole plant of Achillea millefolium. The structure of compound 1 was identified according to spectroscopic data of HRMS and NMR, and its absolute configuration was assigned by 13 C NMR calculations with DP4+ probability analyses and ECD calculations. The absolute configuration of compound 6 was determined by ECD calculations. Compounds 3, 6, 9 and 10 could dose-dependently inhibit the NO release in LPS-induced RAW264.7 cells.
Keyphrases
- lps induced
- density functional theory
- molecular dynamics simulations
- molecular dynamics
- inflammatory response
- magnetic resonance
- high resolution
- monte carlo
- induced apoptosis
- molecular docking
- solid state
- cell cycle arrest
- signaling pathway
- high resolution mass spectrometry
- cell death
- liquid chromatography
- mass spectrometry