TAZ contributes to osteogenic differentiation of periodontal ligament cells under tensile stress.

Yi WangBibo HuRongdang HuXianqin TongMenghan ZhangChuchu XuZhiqi HeYa ZhaoHui Deng

Published in: Journal of periodontal research (2019)

Taken together, we propose that TAZ nucleus localization and its interaction with Cbfα1 are essential for the CTS-induced osteogenic differentiation in PDLCs. And such TAZ activation by CTS could be mediated by ROCK signaling, indicating the pivot role of ROCK-TAZ pathway for PDLCs differentiation.

Keyphrases

induced apoptosis
mesenchymal stem cells
high glucose
cell cycle arrest
bone marrow
oxidative stress
cell death
endothelial cells
endoplasmic reticulum stress
cell proliferation
heat stress