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Preparation of Vinylphosphonates from Ketones Promoted by Tf 2 O.

Nana XinYongzheng LvYongjian LianZhu LinXian-Qiang HuangChang-Qiu ZhaoYanlan Wang
Published in: The Journal of organic chemistry (2023)
An efficient triflic anhydride promoted phosphorylation of ketone was disclosed, and vinylphosphorus compounds were prepared under solvent- and metal-free conditions. Both aryl and alkyl ketones could perform smoothly to give vinyl phosphonates in high to excellent yields. In addition, the reaction was easy to carry out and easy to scale up. Mechanistic studies suggested that this transformation might involve nucleophilic vinylic substitution or a nucleophilic addition-elimination mechanism.
Keyphrases
  • ionic liquid
  • case control
  • molecularly imprinted
  • mass spectrometry