Combining factor VIII levels and thrombin/plasmin generation: A population pharmacokinetic-pharmacodynamic model for patients with haemophilia A.

Laura H BukkemsLars L F G ValkeWideke BartelingBritta A P Laros-van GorkomNicole M A BlijlevensMarjon H CnossenWaander L van HeerdeSaskia E M ScholsRon A A Mathôt

Published in: British journal of clinical pharmacology (2022)

These data suggest that dosing based on patients' individual PK/PD parameters may be beneficial over dosing solely on individual PK parameters. This model could be used as proof-of-principle to examine the application of PK/PD-guided dosing. However, the relation between the PD parameters and bleeding has to be better defined.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
atrial fibrillation
electronic health record
machine learning
data analysis