USP7 Cooperates with NOTCH1 to Drive the Oncogenic Transcriptional Program in T-Cell Leukemia.
Qi JinCarlos A MartinezKelly M ArcipowskiYixing ZhuBlanca T Gutierrez-DiazKenneth K WangMegan R JohnsonAndrew G VolkFeng WangJian WuCharles GroveHui WangIvan SokirniyPaul M ThomasYoung Ah GooNebiyu A AbshiruNobuko HijiyaSofie PeirsNiels VandammeGeert BerxSteven GoossensStacy A MarshallEmily Jane RendlemanYoh-Hei TakahashiLu WangRadhika RawatElizabeth T BartomClayton K CollingsPieter Van VlierbergheAlexandros StrikoudisStephen KellyBeatrix UeberheideChristine MantisIrawati KandelaJean-Pierre BourquinBeat BornhauserValentina SerafinSilvia BresolinMaddalena PaganinBenedetta AccordiGiuseppe BassoNeil L KelleherJoseph WeinstockSuresh KumarJohn D CrispinoAli ShilatifardPanagiotis NtziachristosPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
These results provide a new model for USP7 deubiquitinase activity through recruitment to oncogenic chromatin loci and regulation of both oncogenic transcription factors and chromatin marks to promote leukemia. Our studies also show that targeting USP7 inhibition could be a therapeutic strategy in aggressive leukemia.