A comprehensive and universal approach for embryo testing in patients with different genetic disorders.

Shuo ZhangCaixia LeiJunping WuMin XiaoJing ZhouSaijuan ZhuJing FuDaru LuXiaoxi SunCongjian Xu

Published in: Clinical and translational medicine (2022)

We demonstrate that SNP-based FHLA enables the accurate genetic detection of a wide spectrum of monogenic diseases and chromosome abnormalities in embryos, preventing the transfer of parental genetic abnormalities to the fetus. This method can be implemented as a universal platform for embryo testing in patients with different genetic disorders.

Keyphrases

genome wide
copy number
dna methylation
gene expression
high throughput
pregnant women
pregnancy outcomes
single cell